CV

CURRENT POSITION 


Organization: Barcelona Center for International Health Research (CRESIB) 
Professional category and date of incorporation: Postdoctoral fellow (February 2009) 
Address: Centre de Recerca en Salut Internacional de Barcelona (CRESIB), Hospital Clínic. Rossello 132, 4ª. Barcelona, 08036 Spain. 
Telephone: 932275400 ext 4584

EDUCATION 


PhD “Potential New Therapeutic Agents: Effects on HIV Replication and Viral Escape”. PhD supervisor : José A. Esté, PhD. 
M. Sc. in Immunology, Universitat Autònoma de Barcelona (Spain), 2006. 
B. Sc. in Biology, Universitat de Barcelona (Spain), 2004. 


COURSES 

  • Oct 12  International Good Clinical Practice. Whitehall training. 
  • Aug 10  Introduction to the Systems Biology course. Institute for Systems Biology (Seattle, USA)
  • April 09  Introduction to Good Clinical Practice (GCP). Vienna School of Clinical Research. 
  • May 05  Flow Cytometry Course.  Hospital Universitari Germans Trias i Pujol (Barcelona, Spain).
  • Sep 04   1st Course on Medicinal Chemistry. Institut Químic de Sarrià and Universitat Ramon Llull (Barcelona, Spain). 
  • Jul 00-Aug 00  The cultural revolution of biomolecules. Universitat de Barcelona Summer Courses (Els Juliols de la UB). Faculty of Pharmacy, Universitat de Barcelona (Barcelona, Spain). 
  • Jul 00-Aug 00  Neurodegenerative disease: from the lab to the hospital. Universitat de Barcelona Summer Courses (Els Juliols de la UB). Biochemistry and Molecular Biology Department, Universitat de Barcelona (Barcelona, Spain).
  • Jul 99  Initiation to the Biochemistry and Molecular Biology. Biochemistry and Molecular Biology Department, Universitat de Barcelona and Sociedad Española de Bioquímica y Biología Molecular (Barcelona, Spain). 

PREVIOUS RESEARCH EXPERIENCE 

  • Sep 04-Dec 08 PhD student at Fundació IrsiCaixa (Institut de Recerca de la SIDA de “la Caixa”) Retrovirology Laboratory, Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona, Spain). Research project: Molecular mechanisms of HIV entry and HIV pathology. Development of new antiviral compounds. Supervisor: Dr. José A. Esté. 
  • Feb 04-Jun 04 Training student at the Laboratory of medical virology Centre Nacional de Enterovirus de Lyon, Université Claude Bernard Lyon I (Lyon, France). Research project: Cell entry pathway and haemagglutination of echovirus 6 strains derived from clinical isolates. Supervisor: Prof. Bruno Lina and Dr. Nicolas Lévêque. 
  • Jun 03-Dec 03 Training student at the Immunology and Infectious Diseases Department, Hospital Clínic de Barcelona (Barcelona, Spain). Research project: Generation of HIV neutralizing monoclonal antibodies from HIV patients after HAART interruption. Supervisor: Dr. Teresa Gallart and Dr. Núria Climent. 
  • Apr 02-Oct 02 Training student at the Metabolic engineering and diabetes therapy group, Intitut de Recerca Biomèdica (Barcelona, Spain). Research project: Regulation of hepatic and muscular glycogen metabolism. Alterations in pathological conditions, diabetes mellitus. Supervisor: Prof. Joan Guinovart. 
  • Jun 00-Sep 00 Training student at the Metabolic engineering and diabetes therapy group, Biochemistry and Molecular Biology Department. Universitat de Barcelona (Barcelona, Spain). Research project: Regulation of hepatic and muscular glycogen metabolism. Alterations in pathological conditions, diabetes mellitus. Supervisor: Prof. Joan Guinovart. 

FELLOWSHIPS AND AWARDS 

  • Jan 10- Dec 13 Postdoctoral fellowship: Contrato Posdoctoral de Perfeccionamiento Sara Borrell,  Instituto de Salud Carlos III (Spain).
  • Jan 05-Dec 08 PhD fellowshipDepartament d’Universitats Recerca i Societat de la Informació (DURSI), Generalitat de Catalunya (Spain). 
  • May 07 2nd award graduate student poster category at 20th ICAR, International Conference on Antiviral Research (Palmsprings, USA). 
  • Sep 04-Jan 05 PhD fellowship, Irsicaixa (Barcelona, Spain). 
  • Jun 03-Dec 03 Final year of BSc Collaboration Fellowship from the University of Barcelona at the Immunology and Infectious Diseases Department. Hospital Clínic de Barcelona (Barcelona, Spain). 
  • Sep 02-Jun 03 ERASMUS Exchange Student Fellowship at the University of Bangor (Bangor, UK).

MEETINGS AND WORKSHOPS PRESENTATIONS 

  • 7th European Congress on Tropical Medicine (ECTMIH). Rovira-Vallbona E.*, Moncunill G.*, Bassat Q., Aguilar R., Machevo S., Puyol L., Quintó L., Menéndez C., Chitnis C.E., Alonso P.L., Dobaño C., Mayor A. Low P. falciparum specific antibodies and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children. Barcelona, Spain. October 3-6, 2011. *These authors contributed equally to this work 
  • 7th European Congress on Tropical Medicine (ECTMIH). Moncunill G., Berthoud T., Mayor A., Romagosa C., Serra-Casas E., Rovira-Vallbona E., Quelhas D., Sanz S., Bardají A., Ordi J., Menéndez C., Dobaño C. Cellular-mediated immune factors involved in placental malaria infection. Barcelona, Spain. October 3-6, 2011. 
  • Jornades de Virologia. Moncunill, G., Armand-Ugón M.,Pauls, E., Clotet, B. and Esté, JA. Resistència del VIH-1 a antagonistes de CCR5 mitjançant la selecció in vitro de variants que utilitzen CXCR4 (Oral Presentation). Barcelona (Spain). November 5, 2007. 
  • 20th ICAR, International Conference on Antiviral Research. Moncunill, G., Armand-Ugón, M., Clotet-Codina, I., Llano, A., Vrijbloed, J., Clotet, B., Esté, J.A. The CXCR4 Antagonist POL3026 is a Potent Inhibitor of Human Immunodeficiency Virus (Oral presentation). Palm Springs (USA). April 29-May 3, 2007. 
  • 20th ICAR, International Conference on Antiviral Research. Moncunill, G., Armand-Ugón M., Clotet, B. and Esté, J.A. HIV Coreceptor Switch Induced by Antagonism to CCR5 (Poster attendance). (2nd award graduate student category). Palm Springs (USA). April 29-May 3, 2007. 
  • 20th ICAR, International Conference on Antiviral Research. Senserrich, J., Pauls, E., Clotet-Codina, I., Armand-Ugón, M., Moncunill, G., Clotet, B. and Esté, J.A.HIV-1 Resistance to the Anti-HIV Activity of an shRNA Targeting Rev (Poster). Palm Springs (USA). April 29-May 3, 2007. 
  • Keystone Symposium: Molecular Mechanisms of HIV pathogenesis.Moncunill, G., Armand-Ugón, M., Pauls, E., Clotet, B. and Esté, J.A. HIV Coreceptor Switch Induced by Antagonism to CCR5 (Poster). Whistler (Canada). April 11-14, 2007. 
  • 14th CROI, Conference on Retroviruses and Opportunistic Infections. Moncunill, G., Armand-Ugón, M., Pauls, E., Clotet, B. and Esté, J.A. HIV Coreceptor Switch Induced by Antagonism to CCR5 (Poster attendance). Los Angeles (USA), February 25-28, 2007. 
  • 3rd IAS Conference on HIV Pathogenesis and Treatment. Moncunill G., Negredo E., Vilarrasa J., Clotet B., Esté J.A. Evaluation of the Anti-HIV Activity of Statins (Poster). Rio de Janeiro (Brasil), July 24-27 2005. 

TECHNIQUES AND METHODOLOGY EXPERTISE 


  • Expertise in P3 biosafety laboratory work Most of the techniques described below were carried out in a high level biosafety lab (P3). 
  • Cell and ex vivo cultures
    • Cell culture, including cell lines (adherent, non adherent) and primary cells (lymphocytes, monocytes, macrophages, dendritic cells). 
    • Cell separation (positive and negative magnetic immunoselection). 
    • Tonsils ex vivo cultures. 
  • Flow cytometry 
    • Surface staining, intracellular staining (ICS). 
    • Cytokine multiplex kits (Bender MedSystems, CBA).
    • Dead/Apoptosis assays. 
    • HTS platform (96-well). 
    • FACSCalibur, LSR II, LSRFortessa and FACS CANTO II (Beckton-Dickinson). 
  • Luminex Cytokine and chemokine quantification in culture supernatants and plasma samples.
  • Anti-HIV compounds screening 
    • Obtention and titration of viral stocks (HIV). Antiviral activity in cell lines and primary cells. 
    • Microplate replication, full-plate serial dilutions and reagent addition Robot. (Multimek AP96 Robot, Beckman). 
    • Ca2+ signaling assays. 
  • ELISAS and ELIspots 
    • HIV-p24 antigen, cytokines, antibodies ELISAS. IFNγ and IL2 ELIspots. 
  • Molecular Biology 
    • DNA and RNA extraction and purification.
    • PCR, electrophoresis, digestion, cloning and sequencing (ABI PRISM® 3100-Avant Genetic Analyzer, Applied Biosystems). 
    • Generation of recombinant viruses. Transfection of DNA (Lipofectamine, CalPhos, Amaxa). 
    • Genotyping (Real Time PCR FRED probes, LighClycler Instrument, Roche). 
  • Informatics skills 
    • User-level knowledge (Word, Excel, Power Point, Acces, Visual Basic, SPSS, Endnote, Stata, Mendeley, GraphPad Prism). 
    • Data bases (GenBank, Los Alamos HIV Database, Pubmed). 
    • Bioinformatics (Sequencher, Gendoc, BioEdit, BLAST, ClustalW). 
    • Flow cytometry analysis software (FacsDiva, FCSexpress, FlowJo). 
    • Multimek AP96 Robot Software (Multimek Pro). 
    • ABI PRISM® 3100-Avant integrate data analysis tools. 

LANGUAGES 


  • Catalan
  • Spanish
  • English
  • Portuguese
  • French


 

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